Mathias Lutolf (born in 1973, also known as Matthias Lütolf) is a bio-engineer and a professor at EPFL (École Polytechnique Fédérale de Lausanne) where he leads the Laboratory of Stem Cell Bioengineering. He is specialised in biomaterials, and in combining stem cell biology and engineering to develop improved organoid models. In 2021, he became the scientific director for Roche’s Institute for Translational Bioengineering in Basel.

Lutolf studied materials engineering at ETH Zurich where he graduated in 1998. In 2002, he received his PhD in biomedical engineering from ETH Zurich for his studies on cell-responsive hydrogels for tissue engineering and cell culture, in the group of Jeffrey Hubbell. He completed postdoctoral studies in the laboratory of Helen Blau at Stanford University, where he worked on novel cell culture approaches for blood and muscle stem cells, so-called synthetic niches. In 2007, he founded his own laboratory at EPFL, where he was promoted to associate professor in 2014 and full professor in 2018. From 2014 to 2018, he was director of EPFL’s Institute of Bioengineering. In June 2021, Lutolf became scientific director of the newly established Roche Institute for Translational Bioengineering in Basel, Switzerland.

Lutolf’s laboratory develops in vitro organoids mimicking healthy and diseased tissues and organs. Specifically, Lutolf uses bioengineering strategies to guide stem cell-based development to build novel organoids with improved reproducibility and physiological relevance for basic science and in vitro testing of drug candidates. His team has developed approaches to generate organoids in fully controllable 3D matrices, and has contributed to the understanding of how extrinsic biochemical and physical factors control stem cell fate and organogenesis. His team has developed concepts based on microfabrication, bioprinting, and microfluidics to improve the reproducibility, size, shape, and function of organoids.